Antifungal Activities of Dimeric Sesquiterpenes, Shizukaols C and F, Isolated from Chloranthus japonicus Sieb

• Published in: Journal of microbiology and biotechnology Vol. 27; no. 7; pp. 1272 - 1275
• Main Authors: Kang, Tae Hoon, Lee, Yun Mi, Lee, Won Jung, Hwang, Eui Il, Park, Ki Duk, Choi, Gyang Ja, Moon, Jae Sun, Park, Ho-Yong, Kim, Sung Uk
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국미생물·생명공학회 28.07.2017
• Subjects: Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Fungi - drug effects; Fungicides, Industrial - isolation & purification; Fungicides, Industrial - pharmacology; Magnoliopsida - chemistry; Medicine, Chinese Traditional; Microbial Sensitivity Tests; Phytophthora infestans - drug effects; Plant Diseases - prevention & control; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; 생물학; Phytophthora infestans; shizukaol C; Puccinia recondite; Chloranthus japonicus Sieb; shizukaol F; antifungal activity
• ISSN: 1017-7825; 1738-8872
• DOI: 10.4014/jmb.1612.12051

Two dimeric sesquiterpenes were separated from Sieb. and identified as shizukaols C and F. They exhibited potent antifungal activities (MICs = 4-16 μg/ml) in vitro against various plant pathogenic fungi ( and ). Shizukaol C showed 88% and 91% protective activities in the greenhouse against (wheat leaf rust) and (tomato late blight), respectively, at 100 μg/ml; shizukaol F exhibited 93% antifungal activity against at the same concentration. Therefore, these compounds might serve as interesting candidates for effective antifungal agents.