Comparison of 4-Class and Continuous Fat/Water Methods for Whole-Body, MR-Based PET Attenuation Correction

The goal of this study was to compare two approaches for MR-based PET patient attenuation correction (AC) in whole-body FDG-PET imaging using a tri-modality PET/CT and MR setup. Sixteen clinical whole-body FDG patients were included in this study. Mean standard uptake values (SUVs) were measured for...

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Bibliographic Details
Published inIEEE transactions on nuclear science Vol. 60; no. 5; pp. 3391 - 3398
Main Authors Wollenweber, S. D., Ambwani, S., Lonn, A. H. R., Shanbhag, D. D., Thiruvenkadam, S., Kaushik, S., Mullick, R., Qian, H., Delso, G., Wiesinger, F.
Format Journal Article
LanguageEnglish
Published IEEE 01.10.2013
Subjects
Attenuation
Computed tomography
Image analysis
Image segmentation
Liver
Lungs
magnetic resonance imaging
Positron emission tomography
reconstruction algorithms
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Summary:The goal of this study was to compare two approaches for MR-based PET patient attenuation correction (AC) in whole-body FDG-PET imaging using a tri-modality PET/CT and MR setup. Sixteen clinical whole-body FDG patients were included in this study. Mean standard uptake values (SUVs) were measured for liver and lung volumes-of-interest for comparison. Maximum SUVs were measured in 18 FDG-avid features in 10 of the patients. The AC methods compared to gold-standard CT-based AC were segmentation of the CT (air, lung, fat, water), MR image segmentation with four tissue classes (air, lung, fat, water), and segmentation with air, lung and a continuous fat/water method. Results show that magnitude differences of the uptake values induced by CT-based image segmentation were similar but lower on average than those found using MR-derived AC methods. The average liver SUV difference as compared to using CTAC was 1.3%, 10.4%, and 5.7% for 4-class segmented CT, 4-class MRAC, and continuous fat/water MRAC methods, respectively. The average FDG-avid feature SUVmax difference was -0.5%, 1.7%, and -1.6% for 4-class segmented CT, 4-class MRAC, and continuous fat/water MRAC methods, respectively. The results demonstrated that both 4-class and continuous fat/water AC methods provided adequate quantitation in the body, and that the continuous fat/water method was within 5.7% on average for SUVmean in liver and 1.6% on average for SUVmax for FDG-avid features.
ISSN:0018-9499
1558-1578
DOI:10.1109/TNS.2013.2278759