Nucleus Accumbens Stimulation Modulates Inhibitory Control by Right Prefrontal Cortex Activation in Obsessive-Compulsive Disorder

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 31; no. 5; pp. 2742 - 2758
• Main Authors: Lopez-Sosa, Fernando, Reneses, Blanca, Sanmartino, Florencia, Galarza-Vallejo, Ana, Garcia-Albea, Julia, Cruz-Gomez, Alvaro J, Yebra, Mar, Oliviero, Antonio, Barcia, Juan A, Strange, Bryan A, Gonzalez-Rosa, Javier J
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 31.03.2021
• Subjects: Adult; Biological Variation, Individual; Brain Cortical Thickness; Deep Brain Stimulation - methods; Event-Related Potentials, P300 - physiology; Evoked Potentials, Visual - physiology; Female; Humans; Inhibition, Psychological; Male; Middle Aged; Nucleus Accumbens; Obsessive-Compulsive Disorder - physiopathology; Obsessive-Compulsive Disorder - therapy; Prefrontal Cortex - physiopathology; Young Adult; nucleus accumbens; obsessive-compulsive disorder; prefrontal cortex; deep brain stimulation; response inhibition
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhaa397

Abstract Inhibitory control is considered a compromised cognitive function in obsessive-compulsive (OCD) patients and likely linked to corticostriatal circuitry disturbances. Here, 9 refractory OCD patients treated with deep brain stimulation (DBS) were evaluated to address the dynamic modulations of large-scale cortical network activity involved in inhibitory control after nucleus accumbens (NAc) stimulation and their relationship with cortical thickness. A comparison of DBS “On/Off” states showed that patients committed fewer errors and exhibited increased intraindividual reaction time variability, resulting in improved goal maintenance abilities and proactive inhibitory control. Visual P3 event-related potentials showed increased amplitudes during Go/NoGo performance. Go and NoGo responses increased cortical activation mainly over the right inferior frontal gyrus and medial frontal gyrus, respectively. Moreover, increased cortical activation in these areas was equally associated with a higher cortical thickness within the prefrontal cortex. These results highlight the critical role of NAc DBS for preferentially modulating the neuronal activity underlying sustained speed responses and inhibitory control in OCD patients and show that it is triggered by reorganizing brain functions to the right prefrontal regions, which may depend on the underlying cortical thinning. Our findings provide updated structural and functional evidence that supports critical dopaminergic-mediated frontal-striatal network interactions in OCD.