Uterine transplantation. First viable case in Southern Europe

• Published in: Medicina clinica Vol. 156; no. 6; p. 297
• Main Authors: Carmona, Francisco, Rius, Mariona, Díaz-Feijoo, Berta, Musquera, Mireia, Tort, Jaume, Alcaraz, Antonio
• Format: Journal Article
• Language: English
• Published: Spain 26.03.2021
• Subjects: Adult; Europe; Female; Humans; Organ Transplantation; Quality of Life; Spain; Uterus - diagnostic imaging; Uterus - surgery; Europe; Spain; Trasplante uterino; Rokitansky syndrome; Vaginal stent; Uterine transplantation; Infertility; Factor uterino absoluto; Síndrome de Rokitansky; Absolute uterine factor; Stent vaginal; Infertilidad
• ISSN: 1578-8989
• DOI: 10.1016/j.medcli.2020.12.001

To describe the development and characteristics living donor uterine transplantation program of the Hospital Clínic (Barcelona, Spain) and to report the first successful procedure in Southern Europe. A 31-year-old female suffering of Rokitansky Syndrome underwent uterus transplant from her living sister, as a part of our research protocol. Before the transplant, the patient underwent an in vitro fertilization procedure and twelve embryos were obtained and cryopreserved. The uterus obtention procedure was performed entirely by robotic surgery and lasted 10h, being the main objective to obtain arterial and venous pedicles of good quality in order to ensure the vitality of the graft. The surgical procedure in the recipient was performed by laparotomy and the vascular anastomoses were performed in a terminolateral fashion, with polypropylene 8-0, the vaginal cuff of the graft was sutured to the recipient vaginal vault and the round and utero-sacral ligaments were fixed to the remaining recipient ligaments. Immunosuppressive treatment was prescribed following the protocols from other groups modified according to the solid organ transplantation protocols from our center. The donor and recipient were discharged without any major complications. The recipient ultrasound scan showed a normal flow in both uterine arteries and veins. A grade II rejection was treated with high dose corticoids with subsequent normal biopsies and a vaginal stricture was treated with the placement of an esophageal stent for 4 weeks. The patient had her first menstrual period 47 days after the surgery. The case reported here open new options in Spain for a wide group of patients that had no medical solution for a disease that deeply impairs their quality of life.