Radioimmunodetection of tumors with monoclonal antiplacental ferritin antibody: preliminary results

Two mouse monoclonal antiferritin antibodies were employed to detect tumors. In the first case a solitary hepatoma was defined, while in the second one, mediastinal metastases of breast cancer were detected. In both cases serum ferritin levels were raised. The availability of monoclonal antiferritin...

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Bibliographic Details
Published inOncology Vol. 46; no. 1; p. 35
Main Authors Moroz, C, Lantsberg, Z, Sela, O, Cohen, Y, Khodadadi, J, Goldstein, J, Quastel, M R, Shoenfeld, Y
Format Journal Article
LanguageEnglish
Published Switzerland 1989
Subjects
Aged
Animals
Antibodies, Monoclonal
Breast Neoplasms - diagnosis
Breast Neoplasms - immunology
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - immunology
Female
Ferritins - immunology
Humans
Liver Neoplasms - diagnosis
Liver Neoplasms - immunology
Male
Mice
Placenta - analysis
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Summary:Two mouse monoclonal antiferritin antibodies were employed to detect tumors. In the first case a solitary hepatoma was defined, while in the second one, mediastinal metastases of breast cancer were detected. In both cases serum ferritin levels were raised. The availability of monoclonal antiferritin antibodies offers certain advantages over polyclonal antibodies (ease of production, purification and reproducibility). These antiferritin antibodies may be found useful in diagnosis and therapy of certain tumors.
ISSN:0030-2414
DOI:10.1159/000226677