Multidelay ASL of the pediatric brain

Arterial spin labeling (ASL) is a powerful noncontrast MRI technique for evaluation of cerebral blood flow (CBF). A key parameter in single-delay ASL is the choice of postlabel delay (PLD), which refers to the timing between the labeling of arterial free water and measurement of flow into the brain....

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Bibliographic Details
Published inBritish journal of radiology Vol. 95; no. 1134; p. 20220034
Main Authors Golay, Xavier, Ho, Mai-Lan
Format Journal Article
LanguageEnglish
Published England 01.06.2022
Subjects
Brain - blood supply
Brain - diagnostic imaging
Cerebrovascular Circulation - physiology
Child
Humans
Magnetic Resonance Imaging - methods
Spin Labels
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Summary:Arterial spin labeling (ASL) is a powerful noncontrast MRI technique for evaluation of cerebral blood flow (CBF). A key parameter in single-delay ASL is the choice of postlabel delay (PLD), which refers to the timing between the labeling of arterial free water and measurement of flow into the brain. Multidelay ASL (MDASL) utilizes several PLDs to improve the accuracy of CBF calculations using arterial transit time (ATT) correction. This approach is particularly helpful in situations where ATT is unknown, including young subjects and slow-flow conditions. In this article, we discuss the technical considerations for MDASL, including labeling techniques, quantitative metrics, and technical artefacts. We then provide a practical summary of key clinical applications with real-life imaging examples in the pediatric brain, including stroke, vasculopathy, hypoxic-ischemic injury, epilepsy, migraine, tumor, infection, and metabolic disease.
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ISSN:0007-1285
1748-880X
1748-880X
DOI:10.1259/bjr.20220034