A new bioabsorbable material for rat orthotopic liver transplantation

Rat orthotopic liver transplantation was performed using a newly synthesized bioabsorbable material (LA-GA copolymer) cuffs and the ordinary polyethylene cuffs. The LA-GA copolymer cuff which anastomosed the portal vein was patent and developed no collateral veins even after 6 months, keeping the tr...

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Bibliographic Details
Published inEuropean surgical research Vol. 23; no. 5-6; p. 366
Main Authors Kitakado, Y, Tanaka, K, Asonuma, K, Uemoto, S, Matsuoka, S, Utsunomiya, H, Okamoto, R, Katayama, T, Inomata, Y, Ozawa, K
Format Journal Article
LanguageEnglish
Published Switzerland 1991
Subjects
Anastomosis, Surgical
Animals
Biocompatible Materials
Lactic Acid
Liver Transplantation - methods
Male
Polyethylenes
Polyglycolic Acid
Polymers
Rats
Rats, Inbred Strains
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Summary:Rat orthotopic liver transplantation was performed using a newly synthesized bioabsorbable material (LA-GA copolymer) cuffs and the ordinary polyethylene cuffs. The LA-GA copolymer cuff which anastomosed the portal vein was patent and developed no collateral veins even after 6 months, keeping the transplanted liver normal. By contrast, the polyethylene cuff-anastomosed portal vein was completely occluded and the collateral veins were highly developed, with the transplanted liver showing the fatty degeneration of hepatocytes and numerous regenerative nodules. It is concluded that the LA-GA copolymer cuff is a suitable material for the short- and long-term study of rat orthotopic liver transplantation.
ISSN:0014-312X
DOI:10.1159/000129177