Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye
Therapeutic modalities for posterior-eye diseases involve mostly interventions through the anterior eye, which are difficult for physicians and patients alike. Currently, sustained drug delivery to the posterior eye is gaining importance. A study for sustained delivery of an anti-VEGF agent to the p...
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Published in | Chemical engineering science Vol. 65; no. 18; pp. 5170 - 5177 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
15.09.2010
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Subjects | |
Online Access | Get full text |
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Summary: | Therapeutic modalities for posterior-eye diseases involve mostly interventions through the anterior eye, which are difficult for physicians and patients alike. Currently, sustained drug delivery to the posterior eye is gaining importance. A study for sustained delivery of an anti-VEGF agent to the posterior eye from an implant, made of poly(N-isopropylacrylamide) (NIPAM) and placed episclerally, is presented. The thermally sensitive gel is modelled as a poroelastic material with a phase transition characterized by a lower critical solution temperature (LCST). The study utilizes compartments for various eye tissues, with individual compartments considered to be completely mixed and drug transport between compartments occurring by one-dimensional diffusion. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0009-2509 1873-4405 |
DOI: | 10.1016/j.ces.2010.06.014 |