Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye

Therapeutic modalities for posterior-eye diseases involve mostly interventions through the anterior eye, which are difficult for physicians and patients alike. Currently, sustained drug delivery to the posterior eye is gaining importance. A study for sustained delivery of an anti-VEGF agent to the p...

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Bibliographic Details
Published inChemical engineering science Vol. 65; no. 18; pp. 5170 - 5177
Main Authors Ninawe, Pravin R., Hatziavramidis, Dimitri, Parulekar, Satish J.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 15.09.2010
Subjects
Anti-VEGF agent
Drug macromolecule
Ocular drug delivery
Sclera permeability
Sustained delivery
Thermally responsive gel
Sustained delivery
Drug macromolecule
Thermally responsive gel
Ocular drug delivery
Sclera permeability
Anti-VEGF agent
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Summary:Therapeutic modalities for posterior-eye diseases involve mostly interventions through the anterior eye, which are difficult for physicians and patients alike. Currently, sustained drug delivery to the posterior eye is gaining importance. A study for sustained delivery of an anti-VEGF agent to the posterior eye from an implant, made of poly(N-isopropylacrylamide) (NIPAM) and placed episclerally, is presented. The thermally sensitive gel is modelled as a poroelastic material with a phase transition characterized by a lower critical solution temperature (LCST). The study utilizes compartments for various eye tissues, with individual compartments considered to be completely mixed and drug transport between compartments occurring by one-dimensional diffusion.
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ISSN:0009-2509
1873-4405
DOI:10.1016/j.ces.2010.06.014