Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging

The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging mod...

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Published inOptics express Vol. 20; no. 8; pp. 8726 - 8731
Main Authors Xi, Lei, Grobmyer, Stephen R, Wu, Lei, Chen, Ruimin, Zhou, Guangyin, Gutwein, Luke G, Sun, Jingjing, Liao, Wenjun, Zhou, Qifa, Xie, Huikai, Jiang, Huabei
Format Journal Article
LanguageEnglish
Published United States 09.04.2012
Subjects
Animals
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Disease Models, Animal
Equipment Design
Female
Humans
Imaging, Three-Dimensional
Intraoperative Care - instrumentation
Intraoperative Care - methods
Mice
Neoplasms, Experimental - pathology
Neoplasms, Experimental - surgery
Optical Phenomena
Photoacoustic Techniques - instrumentation
Photoacoustic Techniques - methods
Tomography, Optical - instrumentation
Tomography, Optical - methods
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Abstract The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast.
AbstractList The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast.
Author Zhou, Qifa
Jiang, Huabei
Zhou, Guangyin
Sun, Jingjing
Xi, Lei
Xie, Huikai
Grobmyer, Stephen R
Chen, Ruimin
Liao, Wenjun
Gutwein, Luke G
Wu, Lei
Author_xml – sequence: 1
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  surname: Xi
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  surname: Zhou
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  givenname: Luke G
  surname: Gutwein
  fullname: Gutwein, Luke G
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  fullname: Zhou, Qifa
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  surname: Xie
  fullname: Xie, Huikai
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  givenname: Huabei
  surname: Jiang
  fullname: Jiang, Huabei
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Snippet The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image...
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SubjectTerms Animals
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Disease Models, Animal
Equipment Design
Female
Humans
Imaging, Three-Dimensional
Intraoperative Care - instrumentation
Intraoperative Care - methods
Mice
Neoplasms, Experimental - pathology
Neoplasms, Experimental - surgery
Optical Phenomena
Photoacoustic Techniques - instrumentation
Photoacoustic Techniques - methods
Tomography, Optical - instrumentation
Tomography, Optical - methods
Title Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging
URI https://www.ncbi.nlm.nih.gov/pubmed/22513583
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