Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging

• Published in: Optics express Vol. 20; no. 8; pp. 8726 - 8731
• Main Authors: Xi, Lei, Grobmyer, Stephen R, Wu, Lei, Chen, Ruimin, Zhou, Guangyin, Gutwein, Luke G, Sun, Jingjing, Liao, Wenjun, Zhou, Qifa, Xie, Huikai, Jiang, Huabei
• Format: Journal Article
• Language: English
• Published: United States 09.04.2012
• Subjects: Animals; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Disease Models, Animal; Equipment Design; Female; Humans; Imaging, Three-Dimensional; Intraoperative Care - instrumentation; Intraoperative Care - methods; Mice; Neoplasms, Experimental - pathology; Neoplasms, Experimental - surgery; Optical Phenomena; Photoacoustic Techniques - instrumentation; Photoacoustic Techniques - methods; Tomography, Optical - instrumentation; Tomography, Optical - methods
• ISSN: 1094-4087; 1094-4087
• DOI: 10.1364/OE.20.008726

The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast.