Partial inhibition of oestrogen-induced adenohypophyseal growth by silver nitrate

The administration of silver nitrate to rats in their food (10 mg/rat/day) led to the rapid disappearance of serum polyphenol oxidase activity. After 60 days silver nitrate treatment produced a decrease of adenohypophyseal weight. If given over a period of 40--60 days it also partially inhibited the...

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Bibliographic Details
Published inHormone research Vol. 12; no. 5; p. 296
Main Authors Pribyl, T, Jahodová, J, Schreiber, V
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1980
Subjects
Animals
Body Weight
Ceruloplasmin - blood
Estradiol
Estrogen Antagonists
Laccase
Male
Oxidoreductases - blood
Oxidoreductases - pharmacology
Pituitary Gland, Anterior - drug effects
Pituitary Gland, Anterior - growth & development
Rats
Silver Nitrate - pharmacology
Thyroxine - blood
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Summary:The administration of silver nitrate to rats in their food (10 mg/rat/day) led to the rapid disappearance of serum polyphenol oxidase activity. After 60 days silver nitrate treatment produced a decrease of adenohypophyseal weight. If given over a period of 40--60 days it also partially inhibited the adenohypophyseal response to oestradiol (a weight decrease and raised thyroxine binding by adenohypophyseal proteins in vitro). The mechanism by which silver nitrate diminishes basal and oestrogen-increased adenohypophyseal weight remains unknown.
ISSN:0301-0163
DOI:10.1159/000179133