A cytotoxic pyrrolidinoindoline diketopiperazine dimer from the algal fungus Eurotium herbariorum HT-2

A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino ac...

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Bibliographic Details
Published inChinese chemical letters Vol. 24; no. 12; pp. 1049 - 1052
Main Authors Li, Ye, Sun, Kun-Lai, Wang, Yi, Fu, Peng, Liu, Pei-Pei, Wang, Chen, Zhu, Wei-Ming
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2013
Subjects
Algal fungus
Cristatumin E
Cytotoxicity
Enteromorpha prolifera
Eurotium herbariorum
Marine algae
Pyrrolidinoindoline diketopiperazine dimer
二聚体
二酮
产气肠杆菌
哌嗪
抗菌活性
散囊菌
细胞毒性
藻菌
Cristatumin E
Marine algae
Algal fungus
Pyrrolidinoindoline diketopiperazine dimer
Cytotoxicity
Enteromorpha prolifera
Eurotium herbariorum
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Summary:A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.
Bibliography:Cristatumin E Pyrrolidinoindoline diketopiperazine dimer Eurotium herbariorum Algal fungus Cytotoxicity Enteromorpha prolifera Marine algae
A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.
11-2710/O6
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.07.028