Histiocytic lymphophagocytic panniculitis (Rosai-Dorfman disease): a case report

A 68-year-old woman presented with a symmetrical enlargement of the face and submandibular area associated with essential thrombocytosis. Biopsy of the lesions revealed a septal and lobular panniculitis disclosing a lymphohistiocytic and plasma cell proliferation with lymphophagocytosis by histiocyt...

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Bibliographic Details
Published inDermatology (Basel) Vol. 184; no. 4; p. 317
Main Authors Puppin, Jr, D, Chavaz, P, Harms, M
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1992
Subjects
Aged
Female
Histiocytosis, Sinus - complications
Histiocytosis, Sinus - pathology
Humans
Male
Panniculitis - complications
Panniculitis - pathology
Thrombocytosis - complications
Thrombocytosis - pathology
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Summary:A 68-year-old woman presented with a symmetrical enlargement of the face and submandibular area associated with essential thrombocytosis. Biopsy of the lesions revealed a septal and lobular panniculitis disclosing a lymphohistiocytic and plasma cell proliferation with lymphophagocytosis by histiocytes, compatible with Rosai-Dorfman disease. The lesions regressed spontaneously without therapy over a period of 4 months. Diagnosis was confirmed by electron-microscopic examination and immunocytochemical presence of S-100 antigen within the histiocytic cells. A 2-year follow-up did not demonstrate any evidence of recurrence.
ISSN:1018-8665
DOI:10.1159/000247583