The polymorphism of XRCC1 Arg399Gln (rs25487) and male infertility risk: a meta-analysis of 1,407 cases and 974 control studies

• Published in: Bratislavské lékarské listy Vol. 120; no. 5; p. 349
• Main Authors: Ibrahimi, R, Musavi, M, Shojaee, M, Moossavi, M, Moossavi, S Z, Alaei, M, Poodineh, J, Ibrahimi, M, Farahani, Y, Khorasani, M
• Format: Journal Article
• Language: English
• Published: Slovakia 2019
• Subjects: Case-Control Studies; DNA-Binding Proteins; Genetic Predisposition to Disease; Humans; Infertility, Male - genetics; Male; Polymorphism, Single Nucleotide; Risk Factors; X-ray Repair Cross Complementing Protein 1 - genetics
• ISSN: 0006-9248
• DOI: 10.4149/BLL_2019_057

X-ray repair cross-complementing group 1 (XRCC1) is a scaffold protein and a key element in DNA base excision repair process. Although, the role of XRCC1 polymorphisms in male infertility has been studied broadly, it is still a matter of debate. Hence, in order to shed light on the problem, we performed a meta-analysis to evaluate the overall effect of XRCC1 polymorphisms in male infertility risk. Databases, Web of Science, PubMed, Scopus, and Google Scholar were searched until September 15, 2018. Afterwards, the genotypes' distribution, genotyping methods, and ethnicity groups were extracted, and overall analyses were conducted. A total number of five researches on 1,407 subjects and 974 controls were found to meet our criteria in this meta-analysis. The XRCC1 Arg399Gln (rs25487) polymorphism was analyzed. This is the first meta-analysis to investigate the association of XRCC1 polymorphisms (codon 399) and male infertility risk. Our results indicated that the XRCC1 Arg399Gln polymorphism was not associated with male infertility risk in the total studied populations (Tab. 2, Fig. 3, Ref. 26). Keywords: meta-analysis; male infertility; polymorphism; XRCC1 Arg399Gln.