Sodium-dependent interaction of benzamides with dopamine receptors in rat and dog anterior pituitary glands

Sulpiride and other benzamides' displacement of [3H]-spiroperidol binding to rat and dog anterior pituitary dopaminergic receptors was found to be selectively sodium dependent, while typical neuroleptic activity was not influenced by NaCl. These results indicate the existence in the anterior pi...

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Bibliographic Details
Published inNeuroendocrinology Vol. 32; no. 2; p. 103
Main Authors Stefanini, E, Clément-Cormier, Y, Vernaleone, F, Devoto, P, Marchisio, A M, Collu, R
Format Journal Article
LanguageEnglish
Published Switzerland 01.02.1981
Subjects
Animals
Benzamides - metabolism
Butaclamol - metabolism
Dogs
Male
Pituitary Gland, Anterior - metabolism
Rats
Receptors, Dopamine - drug effects
Receptors, Dopamine - metabolism
Sodium Chloride - pharmacology
Spiperone - metabolism
Sulpiride - metabolism
Tetrahydronaphthalenes - metabolism
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Summary:Sulpiride and other benzamides' displacement of [3H]-spiroperidol binding to rat and dog anterior pituitary dopaminergic receptors was found to be selectively sodium dependent, while typical neuroleptic activity was not influenced by NaCl. These results indicate the existence in the anterior pituitary of a subpopulation of dopaminergic receptors with which benzamides interact.
ISSN:0028-3835
DOI:10.1159/000123139