A new method for radioiodination of polysaccharides and its use in biodistribution studies of an immunomodulating glycoconjugate (Immunoferon)

A new method for the labeling of polysaccharides by using tyrosine derivatives after CNBr activation is presented, along with its use for pharmacokinetic studies of an orally active immunomodulating noncovalent glycoconjugate, which was administered labeled either in the polysaccharide or the protei...

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Bibliographic Details
Published inMethods and findings in experimental and clinical pharmacology Vol. 22; no. 8; p. 621
Main Authors Guerrero, A, Brieva, A, Pivel, J P
Format Journal Article
LanguageEnglish
Published Spain 01.10.2000
Subjects
Adjuvants, Immunologic - blood
Adjuvants, Immunologic - chemistry
Adjuvants, Immunologic - pharmacokinetics
Animals
Calcium Phosphates - blood
Calcium Phosphates - chemistry
Calcium Phosphates - pharmacokinetics
Chromatography, Gel
Gastrointestinal Transit - drug effects
Glycopeptides - blood
Glycopeptides - chemistry
Glycopeptides - pharmacokinetics
Iodine Radioisotopes
Isotope Labeling - methods
Male
Mice
Polysaccharides - chemistry
Tissue Distribution
Tyrosine
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Summary:A new method for the labeling of polysaccharides by using tyrosine derivatives after CNBr activation is presented, along with its use for pharmacokinetic studies of an orally active immunomodulating noncovalent glycoconjugate, which was administered labeled either in the polysaccharide or the protein moiety. The relationship between the obtained results and the mechanism of action are also discussed.
ISSN:0379-0355
DOI:10.1358/mf.2000.22.8.802273