Systemic lupus erythematosus (SLE) presenting with nephrotic syndrome and membranous glomerulopathy in a 10-year-old girl

• Published in: Acta pædiatrica (Oslo) Vol. 94; no. 10; pp. 1507 - 1509
• Main Authors: MACHADO, Vania, PONTES, Teresa, BRITO, Iva, AFONSO, Caldas
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.10.2005
• Subjects: Antibodies, Antinuclear - analysis; Biological and medical sciences; Biopsy, Needle; Child; Cyclophosphamide - administration & dosage; Diagnosis, Differential; Drug Therapy, Combination; Female; Follow-Up Studies; General aspects; Glomerulonephritis; Glomerulonephritis, Membranous - diagnosis; Glomerulonephritis, Membranous - drug therapy; Humans; Immunohistochemistry; Kidney Function Tests; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - drug therapy; Medical sciences; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Nephrotic Syndrome - diagnosis; Nephrotic Syndrome - therapy; Prednisolone - administration & dosage; Risk Assessment; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Severity of Illness Index; Treatment Outcome; Glomerulonephritis; Antineoplastic agent; Pediatrics; intravenous cyclophosphamide; Skin disease; Intravenous administration; Autoimmune disease; Systemic lupus erythematosus; Systemic disease; Female; Lupus erythematosus; Membranous glomerulonephritis; Disseminated; Child; Prednisolone; Human; Kidney disease; Corticosteroid; Connective tissue disease; Urinary system disease; Antiinflammatory agent; Nephrotic syndrome; Alkylating agent; Oxazaphosphinane derivatives; Cyclophosphamide; Nitrogen mustard; Adrenal hormone; Immunosuppressive agent; Inaugural sign
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1080/08035250510039838

The authors report the case of a 10-y-old girl with clinical diagnosis of systemic lupus erythematosus (SLE), made at the age of 6 y, based upon arthritis, serositis, haematological disorder and positive antinuclear antibody. The first manifestation of disease--Raynaud's phenomenon--appeared at the age of 4 y. Seven months after the diagnosis, she developed nephrotic proteinuria with haematuria. Percutaneous renal biopsy showed membranous glomerulonephritis, the least common form of lupus nephritis. Intravenous cyclophosphamide therapy associated with oral prednisolone proved effective in inducing complete remission of nephrotic syndrome.