Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake

• Published in: Bioorganic & medicinal chemistry letters Vol. 14; no. 21; pp. 5395 - 5399
• Main Authors: BOOT, J. R, BRACE, G, RATHMELL, R. E, RICHARDS, S. J, SIMMONDS, R. G, WALLACE, L, WHATTON, M. A, DELATOUR, C. L, DEZUTTER, N, FAIRHURST, J, FINDLAY, J, GALLAGHER, P. T, HOES, I, MAHADEVAN, S, MITCHELL, S. N
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier 01.11.2004
• Subjects: Adrenergic Uptake Inhibitors - chemical synthesis; Adrenergic Uptake Inhibitors - pharmacology; Antidepressive Agents - chemical synthesis; Antidepressive Agents - pharmacology; Biological and medical sciences; Dopamine Plasma Membrane Transport Proteins; Humans; In Vitro Techniques; Medical sciences; Membrane Glycoproteins - metabolism; Membrane Transport Proteins - metabolism; Microsomes, Liver - metabolism; Nerve Tissue Proteins - metabolism; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Norepinephrine - antagonists & inhibitors; Norepinephrine - metabolism; Norepinephrine Plasma Membrane Transport Proteins; Pharmacology. Drug treatments; Propylamines - chemical synthesis; Propylamines - pharmacology; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors - chemical synthesis; Serotonin Uptake Inhibitors - pharmacology; Serotoninergic system; Stereoisomerism; Structure-Activity Relationship; Symporters - metabolism; Thiophenes - chemical synthesis; Thiophenes - pharmacology; Serotonin; Aminoether; Catecholamine; Reuptake inhibitor; In vitro; Sulfur heterocycle; Structure activity relation; Membrane transport; Bicyclic compound; Neurotransmitter; Aromatic compound; Norepinephrine; Inhibition; Chemical synthesis; Carrier protein
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2004.08.005

A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.