Immunological investigations in acute and chronic human pancreatitis

Follow-up immunological studies in 27 patients with acute pancreatitis of known etiology showed a significant elevation in the level of circulating immune complexes (IC), a significant inhibition in migration of leukocytes (with direct LMT) of patients and a significant decrease in the percentage of...

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Published inDigestion Vol. 20; no. 2; p. 100
Main Authors Antal, L, Kávai, M, Szabó, G, Sonkoly, I, Pálóczi, K, Szegedi, G, Sápy, P, Várhelyi, I
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1980
Subjects
Adult
Aged
Antigen-Antibody Complex
B-Lymphocytes - immunology
Cell Migration Inhibition
Female
Humans
Leukocyte Count
Male
Middle Aged
Pancreatitis - immunology
T-Lymphocytes - immunology
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Summary:Follow-up immunological studies in 27 patients with acute pancreatitis of known etiology showed a significant elevation in the level of circulating immune complexes (IC), a significant inhibition in migration of leukocytes (with direct LMT) of patients and a significant decrease in the percentage of T-active, T-total peripheral lymphocytes and in the absolute count of peripheral T cells. Elevated circulating IC levels could been detected 3-4 weeks after the onset of acute pancreatitis. These immunological changes have still been demonstrated in a number of patients 7-14 months after recovery. We have found similar immunological alterations in patients with chronic pancreatitis as well. The possible causes and role of these long-term existing immunologic abnormalities are discussed.
ISSN:0012-2823
DOI:10.1159/000198425