Immunoglobulins A, G, and M to Cytomegalovirus during Recurrent Infection in Recipients of Allogeneic Bone Marrow Transplantation
Occurrence and significance of specific IgA and IgM to cytomegalovirus (CMV) in recurrent CMV infection was evaluated in 21 allogeneic T lymphocyte-depleted bone marrow transplantation (BMT) recipients who had been previously CMV seropositive. Of 17 patients with CMV infection, viruria was detected...
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Published in | The Journal of infectious diseases Vol. 163; no. 3; pp. 628 - 630 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
University Chicago Press
01.03.1991
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | Occurrence and significance of specific IgA and IgM to cytomegalovirus (CMV) in recurrent CMV infection was evaluated in 21 allogeneic T lymphocyte-depleted bone marrow transplantation (BMT) recipients who had been previously CMV seropositive. Of 17 patients with CMV infection, viruria was detected in 94%, CMV-specificIgA in 88% and IgM in 76%, and a fourfold rise in IgG in 65%. The median time between BMT and detection of viruria was 69 days, of IgA 70, of IgM 62, and of IgG 88 days. The IgM and 19A responses lasted for 14 and 30 days (median time), whereas high IgG titers persisted. Twelve patients developed CMV disease; in these the appearance of viruria, 19A, and IgM preceded the rise of IgG (P < .02). CMV-specific 19A and IgM are valuable diagnostic tools in BMT recipients with recurrent CMV infection. |
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Bibliography: | Reprints or correspondence: Dr. D. Engelhard, Department of Pediatrics, Hadassah University Hospital, POB 12000, IL 91120, Jerusalem, Israel. istex:19B0DF694F4D2677778642716B2D8595097677C3 ark:/67375/HXZ-F9DZRW29-8 In memory of Prof. Israel Sarov, who died just before this paper was completed. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1093/infdis/163.3.628 |