Immunoglobulins A, G, and M to Cytomegalovirus during Recurrent Infection in Recipients of Allogeneic Bone Marrow Transplantation

• Published in: The Journal of infectious diseases Vol. 163; no. 3; pp. 628 - 630
• Main Authors: Engelhard, Dan, Weinberg, Miriam, Or, Reuven, Shaked, Oshra, Naparstek, Elisabeth, Haikin, Hava, Slavin, Shimon, Sarov, Israel
• Format: Journal Article
• Language: English
• Published: Chicago, IL University Chicago Press 01.03.1991; University of Chicago Press
• Subjects: Adolescent; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antibodies; Biological and medical sciences; Bone marrow; Bone marrow transplantation; Bone Marrow Transplantation - adverse effects; Bone Marrow Transplantation - immunology; Bone marrow, stem cells transplantation. Graft versus host reaction; Child; Child, Preschool; Concise Communications; Cytomegalovirus; Cytomegalovirus - isolation & purification; Cytomegalovirus infections; Cytomegalovirus Infections - etiology; Cytomegalovirus Infections - immunology; Disease manifestations; Female; Humans; Immunoenzyme Techniques; Immunoglobulin A - analysis; Immunoglobulin G - analysis; Immunoglobulin M - analysis; Immunoglobulins; Infections; Isotypes; Male; Medical sciences; Middle Aged; Recurrence; Time Factors; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Human; Cytomegalovirus; IgA; Seropositivity; Antibody; Herpesviridae; Recurrent; Homotransplantation; Betaherpesvirinae; IgM; Infection; Virus; Viral disease; Bone marrow; Complication; Serum
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/163.3.628

Occurrence and significance of specific IgA and IgM to cytomegalovirus (CMV) in recurrent CMV infection was evaluated in 21 allogeneic T lymphocyte-depleted bone marrow transplantation (BMT) recipients who had been previously CMV seropositive. Of 17 patients with CMV infection, viruria was detected in 94%, CMV-specificIgA in 88% and IgM in 76%, and a fourfold rise in IgG in 65%. The median time between BMT and detection of viruria was 69 days, of IgA 70, of IgM 62, and of IgG 88 days. The IgM and 19A responses lasted for 14 and 30 days (median time), whereas high IgG titers persisted. Twelve patients developed CMV disease; in these the appearance of viruria, 19A, and IgM preceded the rise of IgG (P < .02). CMV-specific 19A and IgM are valuable diagnostic tools in BMT recipients with recurrent CMV infection.