Efficient synthesis of 4-substituted pyrazole via microwave-promoted Suzuki cross-coupling reaction

Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive compounds.In contrast to 3 or 5-aryl pyrazole,the preparation of 4-aryl pyrazole is fairly rare.Utilizing microwave irradiation,the synthesis of 4-substituted-arylpyrazole via Suzuki cross-co...

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Bibliographic Details
Published inChinese chemical letters Vol. 25; no. 5; pp. 705 - 709
Main Authors Cheng, Hua, Wu, Qiong-You, Han, Fan, Yang, Guang-Fu
Format Journal Article
LanguageEnglish
Published NEW YORK Elsevier B.V 01.05.2014
Elsevier
Subjects
4-Aryl pyrazoles
4-Iodo-1-methyl-1H-pyrazole
Chemistry
Chemistry, Multidisciplinary
Microwave irradiation
Physical Sciences
Science & Technology
Suzuki
Suzuki cross-coupling reactions
交叉偶联反应
反应条件
吡唑
微波促进
微波辐射
生物活性化合物
高效合成
Microwave irradiation
4-Aryl pyrazoles
4-Iodo-1-methyl-1H-pyrazole
Suzuki cross-coupling reactions
ASSISTED SYNTHESIS
POTENT
REGIOSELECTIVE SYNTHESIS
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Summary:Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive compounds.In contrast to 3 or 5-aryl pyrazole,the preparation of 4-aryl pyrazole is fairly rare.Utilizing microwave irradiation,the synthesis of 4-substituted-arylpyrazole via Suzuki cross-coupling has been developed with a wide range of substrates.The remarkable advantages of this method are mild reaction conditions,simple operation,high yield,and short reaction time.Product structures were identified by MS 1H NMR 13C NMR,and elemental analysis.
Bibliography:4-Aryl pyrazoles Suzuki cross-coupling reactions 4-Iodo-1-methyl-1H-pyrazole Microwave irradiation
Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive compounds.In contrast to 3 or 5-aryl pyrazole,the preparation of 4-aryl pyrazole is fairly rare.Utilizing microwave irradiation,the synthesis of 4-substituted-arylpyrazole via Suzuki cross-coupling has been developed with a wide range of substrates.The remarkable advantages of this method are mild reaction conditions,simple operation,high yield,and short reaction time.Product structures were identified by MS 1H NMR 13C NMR,and elemental analysis.
11-2710/O6
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.03.013