Effects of somatostatin on gastric secretion and gastrin release in man

Somatostatin, a recently synthesized hypothalamic growth hormone release-inhibiting factor (GIF), was used in the cyclic and linear form. In all subjects studied, the cyclic GIF inhibited gastrin secretion during basal conditions as well as during a standard food stimulus, with immediate rebound aft...

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Bibliographic Details
Published inDigestion Vol. 13; no. 1-2; p. 15
Main Authors Raptis, S, Dollinger, H C, von Berger, L, Schlegel, W, Schröder, K E, Pfeiffer, E F
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1975
Subjects
Gastric Juice - secretion
Gastrins - secretion
Humans
Somatostatin - pharmacology
Time Factors
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Summary:Somatostatin, a recently synthesized hypothalamic growth hormone release-inhibiting factor (GIF), was used in the cyclic and linear form. In all subjects studied, the cyclic GIF inhibited gastrin secretion during basal conditions as well as during a standard food stimulus, with immediate rebound after the infusion was stopped. Similar responses were observed in a hypophysectomized patient, indicating that this effect of GIF was independent of suppression of growth hormone secretion. Cyclic and linear GIF, when administered in normal subjects during an infusion of synthetic human gastrin I, almost totally suppressed gastric secretion. The results indicate that GIF is a potent inhibitor of gastric secretion and gastrin release.
ISSN:0012-2823
DOI:10.1159/000197691