An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2- aminopyrimidine hybrids as highly potent anti-bacterial agents

An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus...

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Bibliographic Details
Published inChinese chemical letters Vol. 25; no. 3; pp. 419 - 422
Main Authors Nagarajan, Sangaraiah, Shanmugavelan, Poovan, Sathishkumar, Murugan, Selvi, Ramasamy, Ponnuswamy, Alagusundaram, Harikrishnan, Hariharan, Shanmugaiah, Vellasamy
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2014
Subjects
1,2,3-Triazole
Antibacterial
Pyrimidine
Water promoted
三唑基
介导
合成
抗菌剂
氨基嘧啶
混合动力车
环保型
金黄色葡萄球菌
Antibacterial
1,2,3-Triazole
Water promoted
Pyrimidine
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Summary:An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.
Bibliography:An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.
11-2710/O6
Water promotedAntibacterial1,2,3-TriazolePyrimidine
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.12.017