Decreased acute thrombogenicity of human umbilical veins after heparin and alcohol treatment

Nine glutaraldehyde-tanned human umbilical veins (GAUV) were incubated in heparin followed by storage in ethyl alcohol 50% (HAUV). These grafts were compared to five GAUV flushed with a heparinized solution without subsequent treatment in alcohol (HsAUV) and four nonheparinized GAUV (NHUV) placed in...

Full description

Saved in:
Bibliographic Details
Published inEuropean surgical research Vol. 15; no. 2; p. 123
Main Authors Esquivel, C O, Björck, C G, Bergqvist, D, Carson, S N, Rothman, U, Bergentz, S E
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1983
Subjects
Animals
Bioprosthesis
Carotid Arteries - surgery
Dogs
Ethanol - pharmacology
Female
Heparin - pharmacology
Humans
Male
Thrombosis - etiology
Umbilical Veins - physiology
Umbilical Veins - transplantation
Online AccessGet more information

Cover

More Information
Summary:Nine glutaraldehyde-tanned human umbilical veins (GAUV) were incubated in heparin followed by storage in ethyl alcohol 50% (HAUV). These grafts were compared to five GAUV flushed with a heparinized solution without subsequent treatment in alcohol (HsAUV) and four nonheparinized GAUV (NHUV) placed in the contralateral carotid arteries of dogs for approximately 3 h. The thrombogenicity was evaluated by measuring the platelet adhesion and aggregation (51Cr), fibrinogen accumulation (125I-fibrinogen), the thrombus-free surface and the thrombus weight. The HAUV had the lowest 51Cr radioactivity. The means of thrombus-free surface and thrombus weight for the grafts were as follows: HAUV, 82% and 0.3 g (n = 9); HsAUV, 53% and 0.6 g (n = 5); NHUV, 13% and 1.2 g (n = 4). The HAUV showed a lower thrombogenicity than both the NHUV and the HsAUV grafts.
ISSN:0014-312X
DOI:10.1159/000128343