Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme

The synthesis of a novel radioactive peptidic photoaffinity probe for the PTP-1B enzyme as well as some SAR leading to the choice of this compound as a photoaffinity probe are presented.

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 14; no. 9; pp. 2319 - 2322
Main Authors THERIEN, Michel, SKOREY, Kathryn, ZAMBONI, Robert, CHUN SING LI, LAU, Cheuk K, LERICHE, Tammy, VOUY LINH TRUONG, WADDLETON, Deena, RAMACHANDRAN, Chidambaram
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 03.05.2004
Subjects
Biological and medical sciences
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Photoaffinity Labels - chemical synthesis
Photoaffinity Labels - chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases - chemistry
Iodine 125
Radiolabelling
Peptides
Enzyme
Phosphoric monoester hydrolases
Esterases
Organic bromine compounds
Organic phosphonate
Photoaffinity labelling
Phosphorus Organic compounds
Structure activity relation
Organic fluorine compounds
Dipeptides
Hydrolases
Protein-tyrosine-phosphatase
Online AccessGet full text

Cover

More Information
Summary:The synthesis of a novel radioactive peptidic photoaffinity probe for the PTP-1B enzyme as well as some SAR leading to the choice of this compound as a photoaffinity probe are presented.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.01.101