Expression and prognostic significance of hsa-miR-142-3p in acute leukemias

• Published in: Neoplasma Vol. 60; no. 4; p. 432
• Main Authors: Dahlhaus, M, Roolf, C, Ruck, S, Lange, S, Freund, M, Junghanss, C
• Format: Journal Article
• Language: English
• Published: Slovakia 2013
• Subjects: Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Female; Humans; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Male; MicroRNAs - analysis; MicroRNAs - physiology; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality; Prognosis
• ISSN: 0028-2685
• DOI: 10.4149/neo_2013_056

The microRNA 142 (miR-142) is expressed at high levels in mature hematopoietic cells and has a crucial role during T-lymphocyte development. Its role in leukemogenesis is unclear. Expression of miR-142 was analyzed in acute myeloid and lymphoblastic leukemia cells (de novo, cell lines). Data were compared to expression in CD34+ hematopoietic cells. Based on the miR-142 expression, clinical data such as overall survival was analyzed. MiR-142 expression in all leukemia cell lines and 86 % of the de novo samples was higher than in CD34+ cells. This difference could be detected in both, myeloid and lymphoid neoplastic cells. In AML patients with intermediate cytogenetic risk a high miR-142 expression was associated with a better overall survival. MiR-142 expression in acute lymphoblastic as well as myeloid leukemia cells is higher than in CD34+ cells. Additionally, miR-142 expression might have prognostic relevance in AML-patients with otherwise an intermediate cytogenetic risk.