Altered Distribution of the Debrisoquine Oxidative Phenotypes in Children with Type 1 Diabetes mellitus

• Published in: Hormone research Vol. 61; no. 4; pp. 176 - 179
• Main Authors: Madácsy, L., Barkai, L., Sánta, A., Krikovszky, D.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2004
• Subjects: Case-Control Studies; Child; Child, Preschool; Cytochrome P-450 CYP2D6 - metabolism; Debrisoquin - metabolism; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - metabolism; Humans; Hydroxylation; Original Paper; Phenotype; Phenotype; Debrisoquine; Cytochrome P450IID6; Type 1 diabetes mellitus
• ISSN: 1663-2818; 0301-0163; 1663-2826
• DOI: 10.1159/000076135

Objective: The recently observed increase in the incidence of type 1 diabetes mellitus (Type 1 DM) suggests a major role of environmental factors in the etiopathogenesis of the disease. The individual variation in cytochrome P 450 IID6 may influence the individual susceptibility to environmentally linked diseases. We aimed to evaluate the prevalence of cytochrome P 450 IID6 phenotypes in Hungarian children with Type 1 DM (n = 69) compared to healthy controls (n = 100). Methods: Debrisoquine was administered orally and debrisoquine hydroxylation phenotype was determined as a metabolic ratio of urinary recovered debrisoquine and 4-hydroxydebrisoquine. Results: Eight of the 100 healthy subjects (8%) and 15 of the 69 diabetic children (22%) (p < 0.05) had cytochrome P 450 IID6 poor metabolizer phenotype (metabolic ratio ≧12.6). Conclusion: Cytochrome P 450 IID6’s activity may play a role in the development of Type 1 DM.