A perceived cluster of amyotrophic lateral sclerosis cases in a Massachusetts community

We investigated a report of a perceived cluster of amyotrophic lateral sclerosis (ALS) in Middleborough, Mass. Although an increase in ALS incidence was observed [2.51 deaths/100,000 person-years (p-y)], relative to the statewide rate over the years 1969-1985 (1.26/100,000 p-y), it was not statistic...

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Bibliographic Details
Published inNeuroepidemiology Vol. 11; no. 4-6; p. 277
Main Authors Proctor, S P, Feldman, R G, Wolf, P A, Brent, B, Wartenberg, D
Format Journal Article
LanguageEnglish
Published Switzerland 1992
Subjects
Adult
Aged
Amyotrophic Lateral Sclerosis - etiology
Amyotrophic Lateral Sclerosis - mortality
Cluster Analysis
Cross-Sectional Studies
Environmental Exposure - adverse effects
Female
Humans
Incidence
Male
Massachusetts - epidemiology
Middle Aged
Risk Factors
Massachusetts
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Summary:We investigated a report of a perceived cluster of amyotrophic lateral sclerosis (ALS) in Middleborough, Mass. Although an increase in ALS incidence was observed [2.51 deaths/100,000 person-years (p-y)], relative to the statewide rate over the years 1969-1985 (1.26/100,000 p-y), it was not statistically significant at the 95% confidence level. Problems in evaluating possible neurological disease clusters and their association with environmental exposures are presented.
ISSN:0251-5350
DOI:10.1159/000110941