Relationship between Survival Days, Cancer Cachexia, and Activities of Daily Living in Palliative Cancer Patients Undergoing Rehabilitation

• Published in: Progress in rehabilitation medicine Vol. 9; p. 20240031
• Main Authors: Oyama, Yuki, Akezaki, Yoshiteru, Kakuta, Takeshi, Sugiura, Mizuki, Fukumura, Yoshiko, Okuma, Keiko, Maeda, Takeshi, Kakehi, Shingo, Saito, Takashi, Goto, Miori, Ikeda, Hiroyoshi, Mukaiyama, Taketo, Yoshizawa, Akitaka
• Format: Journal Article
• Language: English
• Published: Japan JARM 01.01.2024
• Subjects: Original; overall survival; rehabilitation; palliative cancer; activities of daily living; cachexia
• ISSN: 2432-1354; 2432-1354
• DOI: 10.2490/prm.20240031

Cancer cachexia has many effects on physical function and causes a decline in activities of daily living (ADL). Therefore, rehabilitation programs should be structured according to the degree of cancer cachexia. Currently, the evaluation of cancer cachexia is mainly based on body mass. However, there is no report on the use of the modified Glasgow Prognostic Score (mGPS) to evaluate the degree of cancer cachexia and survival prognosis in palliative cancer patients for whom rehabilitation has been prescribed. This study used mGPS to examine the prevalence of cancer cachexia in palliative cancer patients undergoing rehabilitation and the impacts of cancer cachexia, ADL, and complications on survival. The participants included 135 palliative cancer patients who were admitted to the hospital and underwent rehabilitation between 2020 and 2022. Cancer cachexia classification by mGPS was conducted, and logistic regression analysis was used to examine factors affecting the survival of palliative cancer patients undergoing rehabilitation. The patients were grouped as follows: 6 (4.4%) normal, 13 (9.6%) undernourished, 12 (9.0%) pre-cachexia, and 104 (77.0%) refractory cachexia. Logistic regression analysis showed that the mGPS and BI affected survival. In a cohort of palliative cancer patients undergoing rehabilitation, 86% had cachexia. mGPS and BI were associated with survival outcomes. Combination of mGPS classification with ADL assessment may provide meaningful prognostic information in these patients.