Syntheses of new pyridonecarboxylic acid derivatives containing 3-, 5- or 6-quinolyl substituents at N-1 and their anti-HIV-RT activities

A series of new pyridonecarboxylic acid derivatives containing 3-, 5- or 6-quinolyl substituents at N-1 were synthesized and their in vitro anti-HIV-RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine.

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 35; no. 3; pp. 541 - 550
Main Authors Oh, YS, Lee, CW, Chung, YH, Yoon, SJ, Cho, SH
Format Journal Article
LanguageEnglish
Published ODESSA HETERO CORPORATION 01.05.1998
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ACQUIRED CELLULAR IMMUNODEFICIENCY
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Summary:A series of new pyridonecarboxylic acid derivatives containing 3-, 5- or 6-quinolyl substituents at N-1 were synthesized and their in vitro anti-HIV-RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine.
ISSN:0022-152X
DOI:10.1002/jhet.5570350309