Are programmed cell death protein‐1 and Angiopoietins‐2 effective biomarkers for detection the severity of psoriatic patients?

• Published in: Journal of cosmetic dermatology Vol. 21; no. 10; pp. 5208 - 5214
• Main Authors: Khatery, Basma H., Shaker, Olfat G., El‐Tahlawi, Samar, Abd‐elrahim, Talal A., Fawzi, Mai, Ali, Esraa M., Mohammed, Mohammed Hassan
• Format: Journal Article
• Language: English
• Published: England 01.10.2022
• Subjects: angiogenesis; Angiopiotien‐2; pathogenesis; Psoriasis; pathogenesis; Psoriasis; Angiopiotien-2; angiogenesis
• ISSN: 1473-2130; 1473-2165; 1473-2165
• DOI: 10.1111/jocd.15039

Background Early detection of psoriasis is still an open discussion. Psoriatic lesions are characterized by red/scaly plaques affecting different body‐sites. Objectives To evaluate the levels of programmed cell death protein‐1(PD‐1) and Angiopoietins‐2(Ang‐2) in serum, lesional, and perilesional of psoriatic patients and correlate them with controls and disease severity. Subjects and Methods Serum samples were obtained from 40 participants subdivided equally into psoriatic and healthy controls, 4 mm punch_biopsy equally from lesional and perilesional skin of individuals. PD‐1/ANG‐2 ELISA kits were used for determining the serum and tissue levels among groups. Results Serum and tissue levels of PD‐1 and Ang‐2 were overexpressed in psoriatic patients compared with controls. There was a statistical difference between patients and controls in level of PD‐1(serum and tissue) with p‐value 0.006 and 0.0001, respectively. There was a statistical difference between both groups for ANG‐2(serum and tissue) with p‐value 0.03 and 0.0001, respectively. There were positive correlations between PASI score and PD‐1 in tissue (r = 0.467, p = 0.038). Also, positive correlation between the level of PD‐1 in serum and tissue (r = 0.369, p = 0.019), the serum levels of PD‐1 and ANG‐2 (r = 0.78, p > 0.0001), PD‐1 and Ang‐2 in tissue (r = 0.583,p = 0.0001) were detected. Conclusion PD‐1 and ANG‐2 can be highly recommended to determine the severity of psoriasis.