Observation of the clinical efficacy of isotope phosphorus‐32 dressing combined with diprospan and mucopolysaccharide polysulphate cream in the treatment of keloids

• Published in: Journal of cosmetic dermatology Vol. 21; no. 12; pp. 7140 - 7146
• Main Authors: Zhuang, Bin‐yu, Hu, Fang‐chi, You, Yan, Zhang, Liang
• Format: Journal Article
• Language: English
• Published: England 01.12.2022
• Subjects: Bandages; diprospan; Emollients - therapeutic use; Humans; isotope phosphorus‐32 dressing; keloid; Keloid - drug therapy; mucopolysaccharide polysulphate cream; treatment; Treatment Outcome; keloid; isotope phosphorus-32 dressing; treatment; diprospan; mucopolysaccharide polysulphate cream
• ISSN: 1473-2130; 1473-2165
• DOI: 10.1111/jocd.15418

Objective The present study aims to investigate the effectiveness, recurrence, and adverse reaction rates of isotope phosphorus‐32 dressings combined with diprospan and mucopolysaccharide polysulphate cream in the treatment of keloids. Methods A total of 80 patients with keloids admitted to the Dermatology Clinic of the Fourth Affiliated Hospital of Harbin Medical University between June 2019 and June 2021 were included in the present study and randomly divided into three groups: Control Group 1 (n = 27), Control Group 2 (n = 25), and the treatment group (n = 28). Patients in Control Group 1 were treated with diprospan combined with mucopolysaccharide polysulphate cream, patients in Control Group 2 were treated with an isotopic phosphorus‐32 dressing combined with mucopolysaccharide polysulphate cream, and patients in the treatment group were treated with an isotopic phosphorus‐32 dressing combined with diprospan and mucopolysaccharide polysulphate cream. The effectiveness, recurrence, and adverse reaction rates were observed in all three groups. Results The treatment group had the most significant decrease in the itching scores. The respective effectiveness, recurrence, and adverse reaction rates were 81.4%, 43.6%, and 74.1% in Control Group 1; 56%, 38.7%, and 64% in Control Group 2; and 96.7%, 11.2%, and 41% in the treatment group. The differences were statistically significant (p < 0.05). Conclusion An isotope phosphorus‐32 dressing combined with diprospan and mucopolysaccharide polysulphate cream keloid treatment delivers a fast onset, good effectiveness, and low recurrence and adverse effect rates.