Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 24. Synthesis of imidazo[1,5-d]thieno[2,3-b][1,4]thiazine derivatives as potential receptor ligands

A facile synthesis of the imidazo[1,5-d]thieno[2,3-b][1,4]thiazine ring system is described. Reaction of 6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one (1) with potassium tert-butoxide and diethylchlorophosphate gave intermediate 2 which resulted in the disired ring system after adding the...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 39; no. 4; pp. 645 - 648
Main Authors Erker, T, Handler, N
Format Journal Article
LanguageEnglish
Published PROVO HETERO CORPORATION 01.07.2002
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:A facile synthesis of the imidazo[1,5-d]thieno[2,3-b][1,4]thiazine ring system is described. Reaction of 6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one (1) with potassium tert-butoxide and diethylchlorophosphate gave intermediate 2 which resulted in the disired ring system after adding the corresponding isocyanides and potassium tert-butoxide.
ISSN:0022-152X
DOI:10.1002/jhet.5570390407