A Novel Combination of High-Load Omega-3 Lysine Complex (AvailOm ® ) and Anthocyanins Exerts Beneficial Cardiovascular Effects

• Published in: Antioxidants Vol. 11; no. 5; p. 896
• Main Authors: Di Pietro, Paola, Lizio, Rosario, Izzo, Carmine, Visco, Valeria, Damato, Antonio, Venturini, Eleonora, De Lucia, Massimiliano, Galasso, Gennaro, Migliarino, Serena, Rasile, Barbara, Ciccarelli, Michele, Vecchione, Carmine, Carrizzo, Albino
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.04.2022; MDPI
• Subjects: Anthocyanins; Arteries; cardiovascular; Cerebrovascular diseases; Endothelium; Enzymes; Fatty acids; Kinases; Laboratory animals; Low density lipoprotein; Lysine; Nitric oxide; omega-3 lysine complex; Oxidative stress; Statistical analysis; Vascular diseases; Vasoactive agents; Vasodilation; Ann Arbor Michigan; United States > US; Germany; anthocyanins; omega-3 lysine complex; cardiovascular; oxidative stress
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox11050896

Omega-3 fatty acids have been shown to exert several beneficial effects in the prevention of cardiovascular and cerebrovascular diseases. The objective of the present study was to analyze the effects of a novel high-load omega-3 lysine complex, AvailOm , its related constituents and a novel mixture of AvailOm with specific vasoactive anthocyanins on vascular function in mice resistance artery. Pressure myograph was used to perform vascular reactivity studies. Nitric oxide and oxidative stress were assessed by difluorofluorescein diacetate and dihydroethidium, respectively. Increasing doses of AvailOm exerted a dose-response vasorelaxation via AMPK-eNOS-mediated signaling. Omega-3 Ethyl Ester was identified as the main bioactive derivative of AvailOm , being capable of inducing vasorelaxant action to the same extent of entire product. The combination of AvailOm with a mix of potent vasoactive anthocyanins (C3-glu + DP3-glu + Mal3-glu + Mal3-gal + PEO3-gal), strongly protected mesenteric arteries from vascular dysfunction and oxidative stress evoked by oxidized-LDL. These data demonstrate for the first time the direct effects of AvailOm on resistance arteries. The evidence that the combination of specific vasoactive anthocyanins and AvailOm further enhanced the vasculoprotective properties of these compounds, may offer new promising perspectives for preventing the onset of cardiovascular and cerebrovascular events.