Direct functionalization of 4,5-dichloropyridazin-6-one

Direct functionalization of 4,5-dichloropyridazin-6-one with some nucleophiles in seven solvents gave regioselectively 5-halo-4-substituted-pyridazin-6-ones as main product. Reaction of 4,5-dichlorapyridazin-6-one with 2-mercaptopyrimidine (2 equivalents) also afforded 4,5-di(pyrimidin-2-ylsulfanyl)...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 36; no. 4; pp. 905 - 910
Main Authors Chung, HA, Kweon, DH, Kang, YJ, Park, JW, Yoon, YJ
Format Journal Article
LanguageEnglish
Published ODESSA HETERO CORPORATION 01.07.1999
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DERIVATIVES
4,5-DIHALOPYRIDAZIN-6-ONES
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Summary:Direct functionalization of 4,5-dichloropyridazin-6-one with some nucleophiles in seven solvents gave regioselectively 5-halo-4-substituted-pyridazin-6-ones as main product. Reaction of 4,5-dichlorapyridazin-6-one with 2-mercaptopyrimidine (2 equivalents) also afforded 4,5-di(pyrimidin-2-ylsulfanyl)pyridazinone as the main product.
ISSN:0022-152X
DOI:10.1002/jhet.5570360413