Preinfarction Angina Prior to First Myocardial Infarction Does not Influence Long‐Term Prognosis: A Retrospective Study with Subgroup Analysis in Elderly and Diabetic Patients

• Published in: Clinical cardiology (Mahwah, N.J.) Vol. 32; no. 9; pp. E61 - E64
• Main Authors: Jiménez‐Navarro, Manuel F., Muñoz‐García, Antonio, Ramirez‐Marrero, Miguel A., Dominguez‐Franco, Antonio, García Alcántara, Angel, José Gómez‐Doblas, Juan, Alonso‐Briales, Juan, María Hernández‐García, José, Salva, Dolores, Rodriguez‐Losada, N., de Teresa, Eduardo
• Format: Journal Article
• Language: English
• Published: New York Wiley Periodicals, Inc 01.09.2009
• Subjects: Aged; Angina Pectoris - complications; Angina Pectoris - mortality; Angina Pectoris - therapy; Angina, Unstable - etiology; Case Report; Case Reports; Diabetes Complications - mortality; Diabetes Complications - therapy; Heart Failure - etiology; Hospitalization; Humans; Middle Aged; Myocardial Infarction - complications; Myocardial Infarction - mortality; Myocardial Infarction - therapy; Patient Readmission; Proportional Hazards Models; Recurrence; Retrospective Studies; Risk Assessment; Risk Factors; Thrombolytic Therapy - adverse effects; Thrombolytic Therapy - mortality; Time Factors; Treatment Outcome
• ISSN: 0160-9289; 1932-8737; 1932-8737
• DOI: 10.1002/clc.20513

Background and hypothesis Although prodromal angina occurring shortly before an acute myocardial infarction (MI) has protective effects against in‐hospital complications, this effect has not been well documented after initial hospitalization, especially in older or diabetic patients. We examined whether angina 1 week before a first MI provides protection in these patients. Methods A total of 290 consecutive patients, 143 elderly (>64 years of age) and 147 adults (<65 years of age), 68 of whom were diabetic (23.4%) and 222 nondiabetic (76.6%), were examined to assess the effect of preceding angina on long‐term prognosis (56 months) after initial hospitalization for a first MI. Results No significant differences were found in long‐term complications after initial hospitalization in these adult and elderly patients according to whether or not they had prodromal angina (44.4% with angina vs 45.4% without in adults; 45.5% vs 58% in elderly, P < 0.2). Nor were differences found according to their diabetic status (61.5% with angina vs 72.7% without in diabetics; 37.3% vs 38.3% in nondiabetics; P = 0.4). Conclusion The occurrence of angina 1 week before a first MI does not confer long‐term protection against cardiovascular complications after initial hospitalization in adult or elderly patients, whether or not they have diabetes. Copyright © 2009 Wiley Periodicals, Inc.