Modulation of skin androgenesis and sebum production by a dermocosmetic formulation

• Published in: Journal of cosmetic dermatology Vol. 20; no. 1; pp. 360 - 365
• Main Authors: Crocco, Elisete Isabel, Bonifácio, Evellin Barbosa, Facchini, Gustavo, Silva, Gustavo Henrique, Silva, Michelle Sabrina, Pinheiro, Ana Lucia Tabarini Alves, Avelar, Paula Voltarelli Franco, Eberlin, Samara
• Format: Journal Article
• Language: English
• Published: England 01.01.2021
• Subjects: 5α reductase; acne vulgaris; Acne Vulgaris - drug therapy; androgen; Androgens; dihydrotestosterone; Humans; sebaceous gland; Sebaceous Glands; Sebum; Skin; acne vulgaris; androgen; sebaceous gland; sebum; 5α reductase; dihydrotestosterone

Background Excessive androgenesis in the skin promotes sebaceous hyperproduction which is the onset of acne vulgaris pathogenesis. Free fatty acids and lipid accumulation in the glandular infundibulum culminates in microbiota imbalance, triggering inflammatory response and follicular hyperkeratiniza...