SYNTHESIS OF THE CARDIOTONIC BEMARINONE, 5,6-DIMETHOXY-4-METHYL-2(1H)-QUINAZOLINONE, UTILIZING A DIRECTED METALATION APPROACH

Several methods for the synthesis of bemarinone, 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone were explored with the most successful being a directed metalation route. Details of the lithiation and the subsequent reaction with electrophiles of 3',4'-dimethoxy-2,2-dimethylpropioanilide and ot...

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Published inJournal of heterocyclic chemistry Vol. 32; no. 3; pp. 761 - 770
Main Authors CONLEY, RA, BARTON, DL, STEFANICK, SM, LAM, MM, LINDABERY, GC, KASULANIS, CE, CESCOCANCIAN, S, CURREY, S, FABIAN, AC, LEVINE, SD
Format Journal Article
LanguageEnglish
Published TAMPA HETERO CORPORATION 01.05.1995
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ACID
LITHIATION
POLYSUBSTITUTED AROMATICS
QUINAZOLINES
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Summary:Several methods for the synthesis of bemarinone, 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone were explored with the most successful being a directed metalation route. Details of the lithiation and the subsequent reaction with electrophiles of 3',4'-dimethoxy-2,2-dimethylpropioanilide and other derivatives of 3,4-dimethoxyaniline are given.
ISSN:0022-152X
DOI:10.1002/jhet.5570320312