Synthesis of pyrimido[4,5-b]quinolines in the reaction of 6-aminopyrimidines with dimedone and benzaldehydes

The reaction of 6-aminopyrimidines 1a,b with dimedone (2) and p-substituted benzaldehydes 3a-d in ethanol afforded in all cases new regiospecific synthesis of tricyclic, linear 5-aryl-5,6,7,8,9,10-hexahydropyrimido[4,5-b]quinolines 4a-h in good yields, The linear structures and hence the regiospecif...

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Published inJournal of heterocyclic chemistry Vol. 35; no. 1; pp. 231 - 233
Main Authors Quiroga, J, Hormaza, A, Insuasty, B, Ortiz, AJ, Sanchez, A, Nogueras, M
Format Journal Article
LanguageEnglish
Published ODESSA HETERO CORPORATION 01.01.1998
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
POTENTIAL ANTITUMOR AGENTS
1,4-DIHYDROPYRIDINES
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Summary:The reaction of 6-aminopyrimidines 1a,b with dimedone (2) and p-substituted benzaldehydes 3a-d in ethanol afforded in all cases new regiospecific synthesis of tricyclic, linear 5-aryl-5,6,7,8,9,10-hexahydropyrimido[4,5-b]quinolines 4a-h in good yields, The linear structures and hence the regiospecificity of the reaction were established by nmr measurements.
ISSN:0022-152X
DOI:10.1002/jhet.5570350142