Nitro derivatives from the Arctic ice bacterium Salegentibacter sp. isolate T436

• Published in: Journal of antibiotics Vol. 62; no. 8; pp. 453 - 460
• Main Authors: Schuhmann, Imelda, Yao, Clarisse B Fotso-Fondja, Al-Zereini, Wael, Anke, Heidrun, Helmke, Elisabeth, Laatsch, Hartmut
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2009; Nature Publishing Group
• Subjects: Arctic Regions; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Chromatography, High Pressure Liquid; Dinitrophenols - chemistry; Dinitrophenols - metabolism; Fermentation; Flavobacteriaceae - chemistry; Flavobacteriaceae - classification; Flavobacteriaceae - metabolism; Ice; Indicators and Reagents; Life Sciences; Magnetic Resonance Spectroscopy; Medicinal Chemistry; Microbiology; Molecular Conformation; Nitro Compounds - chemistry; Nitro Compounds - metabolism; Organic Chemistry; original-article; Pack ice; Phenols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Arctic Regions; aromatic nitro compounds; marine bacteria
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2009.71

Twenty-five aromatic nitro, dinitro and trinitro compounds were isolated in low yields of less than 1 mg l −1 from a Salegentibacter sp. strain T436 derived from Arctic pack ice. Their structures were elucidated by MS and NMR techniques. Seven of these compounds, namely, 2-hydroxy-3-(4′-hydroxy-3′-nitrophenyl)-propionic acid methyl ester ( 6 ), 2-chloro-3- (4′-hydroxy-3′-nitrophenyl)propionic acid methyl ester ( 7 ), 3-(4′-hydroxy-3′,5′-dinitrophenyl)-propionic acid methyl ester ( 14 ), 4′-hydroxy-3′,5′-dinitrophenylethylchloride ( 16 ), (4′-hydroxy-3′,5′-dinitrophenyl)-2-chloropropionic acid methyl ester ( 17 ), N -acetyl-3′,5′-dinitrotyramine ( 18 ) and 2,6-dinitro-4-(2′-nitroethenyl)phenol ( 19 ) are new, and five are reported in this study from a natural source for the first time.