Synthesis of methyl derivatives of linear and angular thienocoumarins and thiopyranocoumarins

New linear and angular thienocoumarins and thiopyranocoumarins were synthesized. The key intermediates were appropriate methyl derivatives of 7-mercaptocoumarin, which were condensed with chloroketones or propargyl chloride. Thioethers were cyclized under various conditions in order to determine whi...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 35; no. 4; pp. 847 - 852
Main Authors Rodighiero, P, Pastorini, G, Chilin, A, Marotto, A
Format Journal Article
LanguageEnglish
Published HOBOKEN Wiley 01.07.1998
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ANALOGS
POTENTIAL PHOTOREAGENTS
DNA
PSORALEN
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Summary:New linear and angular thienocoumarins and thiopyranocoumarins were synthesized. The key intermediates were appropriate methyl derivatives of 7-mercaptocoumarin, which were condensed with chloroketones or propargyl chloride. Thioethers were cyclized under various conditions in order to determine which methods produced the best yields of the desired thienocoumarins 15, 16, 17, 18, 22, 23, 24, 27 and thiopyranocoumarins 28 and 29.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570350411