Multi-scale adaptions of dynamic bio-interfaces

• Published in: Smart materials in medicine Vol. 3; pp. 37 - 40
• Main Authors: Zhao, Qilong, Du, Xuemin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 2022; KeAi Communications Co., Ltd
• Subjects: Biodevices; Biomaterials; Dynamic bio-interfaces; Multi-scale adaptions; Responsive polymers; Dynamic bio-interfaces; Responsive polymers; Multi-scale adaptions; Biodevices; Biomaterials
• ISSN: 2590-1834; 2590-1834
• DOI: 10.1016/j.smaim.2021.12.001

Biodevices including wearable sensors, medical implants or protheses (e.g., tissue engineering scaffolds and neural electrodes), have attracted extensive attentions over the past several decades due to their great potentials in multiple areas of healthcare, diagnostics, and rehabilitation. The performances and efficiency of biodevice-tissue integration and adaption are significantly affected by their bio-interfaces, which should be therefore carefully considered and optimized. This perspective briefly summarizes the emerging biodevices with bio-inspired dynamic bio-interfaces for accommodating the dynamic natures of cell functions or human body tissues on molecular-, nano-/micro-, and macro-scales, which hold promises to bring in breakthroughs to some future technologies such as personalized medicine, artificial organs, and human-machine interaction and integration. Biodevices including wearable sensors, medical implants or protheses (e.g., tissue engineering scaffolds, and neural electrodes), have attracted extensive attentions over the past several decades due to their great potentials in multiple areas of healthcare, diagnostics, and rehabilitation. The performances and efficiency of biodevice-tissue integration and adaptation are significantly affected by their bio-interfaces, which should be therefore carefully considered and optimized. This perspective briefly summarizes the emerging biodevices with bio-inspired dynamic bio-interfaces for accommodating the dynamic natures of human body tissues or cell functions on molecular, nano/micro-, and macro-scales, which hold promises to bring in breakthroughs to some future technologies such as personalized medicine, artificial organs, and human-machine interaction and integration. [Display omitted] •The importance of developing dynamic bio-interfaces to mimic the native bio-interactions in multi-scale manners for achieving enhanced bio-adaptative outcomes.•Molecular-scale bio-adaptation of dynamic bio-interfaces for enhancing interactions with cells.•Micro-/nano-scale bio-adaptation of dynamic bio-interfaces for regulating cell functions.•Macro-scale bio-adaptation of dynamic bio-interfaces for promoting stable and long-term interactions between the biodevices and tissues.•Challenges and prospective of dynamic bio-interfaces for potential applications are outlooked.