Comparative study of 15% trichloroacetic acid peel combined with 70% glycolic acid and 35% trichloroacetic acid peel for the treatment of photodamaged facial skin in aging women

• Published in: Journal of cosmetic dermatology Vol. 19; no. 1; pp. 137 - 146
• Main Authors: Kubiak, Marlena, Mucha, Paulina, Rotsztejn, Helena
• Format: Journal Article
• Language: English
• Published: England 01.01.2020
• Subjects: chemical peels; glycolic acid; photodamaged skin; trichloroacetic acid; photodamaged skin; glycolic acid; chemical peels; trichloroacetic acid
• ISSN: 1473-2130; 1473-2165; 1473-2165
• DOI: 10.1111/jocd.13171

Background Photoaging (extrinsic aging) is caused by environmental exposure to ultraviolet radiation. Superficial and medium‐depth chemical peels with trichloroacetic acid (TCA) are performed to reduce wrinkles, hyperpigmentation, dryness, and erythema caused by photoaging process. Aim The aim of this study was to compare the efficacy and tolerability of 15% TCA peel against the combined 70% glycolic acid and 35% TCA for the treatment of photodamaged facial skin. Patients/Methods Forty female patients with types II and III of Glogau photoaging scale were divided into two groups of twenty subjects (GA/TCA and 35% TCA). The GA/TCA group was treated with combination peeling of 70% GA and 15% TCA, whereas the 35% TCA group was treated with monopeeling of 35% trichloroacetic acid. Each patient was submitted to five sessions of these peels, with an interval of 14 days between each session. The following skin aging parameters were examined before treatments, before each session, and 3 months after the last application: hydration, elasticity, melanin index, and erythema index (MPA‐5; Courage‐Khazaka, Germany); and depth and volume of wrinkles (PRIMOS; GFMesstechnik GmbH, Germany). Results Both peel methods achieved significant improvement in all skin parameters: elasticity, hydration, melanin index, and erythema index. Significant differences between the GA/TCA and 35% TCA groups were found only for hydration and melanin index. GA/TCA was characterized by significantly higher values of the hydration parameter and lower values of melanin index compared with 35% TCA. Combination peel GA/TCA did not cause dryness, edema, or intensive lysis of the epidermis, and the frequency of peel‐induced erythema did not increase with the addition of glycolic acid, but with higher concentration of the TCA solution. However, subject‐perceived improvements of the 35% TCA peel did not differ significantly from subject‐perceived improvements of combination peel treatment. Adverse events requiring intervention or discontinuing treatment were not observed in either group. Conclusion The addition of glycolic acid before 15% TCA chemical peel application significantly enhanced TCA‐induced improvement in photoaging parameters (increase in skin elasticity and hydration; reduction in melanin index and erythema index), and subject‐perceived improvements. However, 35% TCA peel is more effective in reducing wrinkles, despite a lower tolerability. Both medium‐depth chemical peels including 15% TCA in combination with 70% GA and 35% TCA alone proved to be useful for the removal of epidermal or superficial lesions and to improve the texture of photodamaged facial skin (grade II‐III Glogau photoaged skin).