Serum Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Level in Patients with Hepatocellular Carcinoma

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 22; no. 11; pp. 3521 - 3524
• Main Authors: Sripariwuth, Ekawee, Piwchan, Setthachai, Pongcharoen, Sutatip
• Format: Journal Article
• Language: English
• Published: Thailand West Asia Organization for Cancer Prevention 01.11.2021
• Subjects: Adult; Alanine Transaminase - blood; Alkaline Phosphatase - blood; Antigens, CD - blood; Aspartate Aminotransferases - blood; Bilirubin - blood; Carcinoma, Hepatocellular - blood; Case-Control Studies; Cell Adhesion Molecules - blood; Female; Humans; Liver Neoplasms - blood; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; HCC; Hepatocellular carcinoma; Serum; CEACAM1
• ISSN: 1513-7368; 2476-762X
• DOI: 10.31557/APJCP.2021.22.11.3521

To evaluate the clinical value of carcinoembryonic-antigen-related cell-adhesion molecule 1 (CEACAM1) in predicting the severity of hepatocellular carcinoma(HCC). We evaluated 40 healthy subjects and 40 HCC patients by collecting venous blood for the comparison. Serum CEACAM1 was detected using the Human CEACAM1 ELISA Kit. Other laboratory chemistries were analyzed by standard methods. The serum level of CEACAM1 was not different between HCC patients and healthy subjects (p=0.0069). There was a correlation between serum CEACAM1 level and total bilirubin, and direct bilirubin. There was also a statistically significant difference among serum CEACAM1 levels stratified by BCLC staging and MELD score at the cut-point of 18. Lower platelet count, higher levels of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were observed in HCC patients. An increase of serum CEACAM1 level was associated with cholestasis. The role of this molecule in HCC diagnosis was unclear. However, serum CAECAM1 may be useful to predict the severity in HCC patients.