Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines

The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitr...

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Published inJournal of heterocyclic chemistry Vol. 37; no. 5; pp. 1273 - 1275
Main Authors Abdel-Jalil, RJ, Al-Qawasmeh, RA, Voelter, W, Heeg, P, El-Abadelah, MM, Sabri, SS
Format Journal Article
LanguageEnglish
Published ODESSA HETERO CORPORATION 01.09.2000
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
RECEPTOR
AGENTS
ANTIBACTERIALS
ACIDS
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Summary:The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coli ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC10231.
ISSN:0022-152X
DOI:10.1002/jhet.5570370541