Syntheses of arylsulfonyl-1,3,4-thiadiazoles
Reaction of sodium arylsulfinate with 2-aryl-5-chloro-1,3,4-thiadiazole gave 2-aryl-5-arylsulfonyl-1,3,4-thiadiazole (3) in good yield. Starting from readily available 2-amino-5-benzylmercapto-1,3,4-thiadiazole compound 7 was obtained in three steps in moderate yield. Reaction of compound 7 with sod...
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Published in | Journal of heterocyclic chemistry Vol. 33; no. 6; pp. 1611 - 1614 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
MALDEN
Wiley
01.11.1996
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Subjects | |
Online Access | Get more information |
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Summary: | Reaction of sodium arylsulfinate with 2-aryl-5-chloro-1,3,4-thiadiazole gave 2-aryl-5-arylsulfonyl-1,3,4-thiadiazole (3) in good yield. Starting from readily available 2-amino-5-benzylmercapto-1,3,4-thiadiazole compound 7 was obtained in three steps in moderate yield. Reaction of compound 7 with sodium arylsulfinate afforded 2,5-diarylsulfonyl-1,3,4-thiadiazole (11). Oxidation of compound 10 with hydrogen peroxide in acetic acid gave 2-arylsulfonyl-5-benzylsulfonyl-1,3,4-thiadiazole (12), in high yield. |
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ISSN: | 0022-152X |
DOI: | 10.1002/jhet.5570330610 |