Acute effects of the synthetic analogue of methionine enkephalin FK 33-824 on depressive symptoms

Nine patients with endogenous depression have been treated with infusions of the synthetic methionine enkephaline analogue FK 33-824 for two days. Only on the first day acute effects on depressive symptoms could be observed. It cannot be decided if the observed mood alterations on the first treatmen...

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Bibliographic Details
Published inPharmacopsychiatria Vol. 16; no. 3; p. 90
Main Authors Jungkunz, G, Nedopil, N, Rüther, E
Format Journal Article
LanguageEnglish
Published Germany 01.05.1983
Subjects
Adult
Aged
Antidepressive Agents - therapeutic use
Clinical Trials as Topic
D-Ala,MePhe,Met-ol-enkephalin
Depressive Disorder - drug therapy
Depressive Disorder - psychology
Enkephalin, Methionine - analogs & derivatives
Enkephalin, Methionine - therapeutic use
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
Online AccessGet more information

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Summary:Nine patients with endogenous depression have been treated with infusions of the synthetic methionine enkephaline analogue FK 33-824 for two days. Only on the first day acute effects on depressive symptoms could be observed. It cannot be decided if the observed mood alterations on the first treatment day are placebo effects. Depressive patients showed fewer adverse reactions than healthy volunteers. This might be explained by the previously described greater pain tolerance in depressives.
ISSN:0720-4280
DOI:10.1055/s-2007-1017456