Structural characterisation of amorphous solid dispersions via metropolis matrix factorisation of pair distribution function data

We measure the X-ray pair distribution functions (PDFs) of a series of felodipine:copovidone amorphous solid dispersions. Using a newly-developed Metropolis Matrix Factorisation (MMF) algorithm we extract from these data the PDF of the amorphous felodipine component in isolation. Our MMF analysis al...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 55; no. 89; pp. 13346 - 13349
Main Authors Geddes, Harry S., Blade, Helen, McCabe, James F., Hughes, Leslie P., Goodwin, Andrew L.
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 18.11.2019
Subjects
Algorithms
Amorphous structure
Computer simulation
Crystal structure
Crystallinity
Dispersions
Distribution functions
Factorization
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Summary:We measure the X-ray pair distribution functions (PDFs) of a series of felodipine:copovidone amorphous solid dispersions. Using a newly-developed Metropolis Matrix Factorisation (MMF) algorithm we extract from these data the PDF of the amorphous felodipine component in isolation. Our MMF analysis allows quantification of the degree of drug crystallinity in each sample, and structural characterisation of the amorphous drug via its PDF. Comparison with atomistic simulations reveals that the (in)accessibility of conformational rotamers distinguishes amorphous and crystalline felodipine, in turn suggesting design routes for stabilising the amorphous form. We discuss the conceptual importance of our results in the context of characterising not only amorphous pharmaceuticals, but complex mixtures in general.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc06753a