Case-control study of IDDM
Case-control study of IDDM. J Siemiatycki , E Colle , S Campbell , R A Dewar and M M Belmonte Centre de recherche en épidémiologie et médecine préventive, Institut Armand-Frappier, Laval-des-Rapides, Quebec, Canada. Abstract Insulin-dependent diabetes mellitus (IDDM) may be caused by a combination o...
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Published in | Diabetes care Vol. 12; no. 3; pp. 209 - 216 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Diabetes Association
01.03.1989
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Subjects | |
Online Access | Get full text |
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Summary: | Case-control study of IDDM.
J Siemiatycki ,
E Colle ,
S Campbell ,
R A Dewar and
M M Belmonte
Centre de recherche en épidémiologie et médecine préventive, Institut Armand-Frappier, Laval-des-Rapides, Quebec, Canada.
Abstract
Insulin-dependent diabetes mellitus (IDDM) may be caused by a combination of genetic predisposition and environmental insults.
However, there are few solid leads concerning human diabetogenic environmental agents. A case-control study was carried out
to investigate the possible relationships between IDDM and various biological, chemical, and psychological factors. All 161
cases of IDDM among children aged 0-17 yr occurring in Montreal from 1983 to 1986 were included. The parent of each newly
diagnosed diabetic subject was asked to provide the names of two of the child's friends or neighbors who would be age and
sex matched to serve as controls. For those unable to do so, matched controls were selected from a hospital emergency room.
Parents of cases and controls were interviewed concerning many factors. There was little or no difference between cases and
controls with regard to parental smoking habits, exposure to pets, and consumption of meat products high in nitrosamines.
In univariate analyses, there was some indication of elevated risk for children who had not been breast-fed, who attended
day care or nursery before age 5 yr, who lived in a crowded household at age 3 yr, or who had a history of asthma or eczema,
although in multivariate analyses the only variables that had any effect were crowding and day-care attendance. In univariate
and multivariate analyses, there was high risk of IDDM among children who had experienced selected stressful life events during
the 12 mo preceding onset of IDDM or who had exhibited symptoms of social or psychological dysfunction during that time. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0149-5992 1935-5548 |
DOI: | 10.2337/diacare.12.3.209 |