A switching control strategy for improving drug infusion

• Published in: International journal of control Vol. 82; no. 12; pp. 2221 - 2234
• Main Authors: Neves, A.J., Mendonça, T., Rocha, P.
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis Group 01.12.2009; Taylor & Francis
• Subjects: Applied sciences; Biological and medical sciences; biomedical application; Computer science; control theory; systems; Control system synthesis; Control theory. Systems; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; Medical sciences; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; switching control; tracking; Vertebrates: nervous system and sense organs; Biotechnology; Multimodel control; Tracking; Surgery; Tracking(movable target); Control synthesis; Neuromuscular transmission; Modeling
• ISSN: 0020-7179; 1366-5820
• DOI: 10.1080/00207170902978107

A switching control strategy for drug infusion in patients undergoing surgery is presented in this article. This strategy is based on a bank of stabilising controllers, aiming to improve the reference tracking performance of the patient response. Theoretical results which ensure overall stability and reference tracking under switching are obtained. These results are illustrated by simulations for the case of neuromuscular blockade control which show that, in this biomedical application, this switching controller yields better performance than a fixed one. The proposed control scheme also presents a good performance in clinical environment.